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There's a proton transfer with the sure water molecule to Asp-273 which is followed by nucleophilic assault around the carbonyl carbon and development of the tetrahedral intermediate. The collapse from the tetrahedral intermediate is facilitated by proton transfer from Asp-273 on the leaving group amine in the merchandise, d-glucosamine-6-phosphate. The solutions depart the active internet site and A different round of catalysis commences Using the charging on the metal Middle by using a molecule of drinking water through the solvent.
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A female naga is called a "nagi" or "nagini". A nagaraja can be a king of the nagas.[three] They are really typical in Indian mythology and Perform a vital purpose in several religious traditions.
Since the legend goes, Kaundinya acquired instruction in a aspiration to have a magic bow from the temple and defeat Soma, the nāga princess and daughter on the nāga king. For the duration of the following battle, they fell in like and afterwards married, creating the royal lineage of the Funan dynasty.
enzyme can bind but a single divalent cation from the active web-site. For the binuclear steel Centre, the activation on the amide bond as well as activation in the solvent h2o might be distributed independently in between The 2 metal ions. However, from the mononuclear metal Middle, both capabilities need to be borne by an individual divalent cation. These results highlight the numerous variety with the evolution of functionality within the amidohydrolase superfamily.
Mutation of H143 to an asparagine resulted during the remarkable lack of catalytic activity in addition to a reasonable boost in the K
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Renewed violence transpired during the State from the center in the nineteen eighties. The fratricidal confrontations among the various Naga teams and the Condition authorities led into the loss of lives, disturbed community get and thwarted the economic growth of your State.
Naga tribemen donning warpaint c. 1905 Apart from producing contacts Using the Ahom kingdom, the Nagas normally lived an isolated existence from the skin environment. In the course of the 19th century, the British tried to subjugate the Naga tribes and abolish standard Naga practices like headhunting and intertribal violence.